Inactivation of West Nile virus, vaccinia virus and viral surrogates for relevant and emergent viral pathogens in plasma-derived products
نویسندگان
چکیده
منابع مشابه
West Nile viral encephalitis.
West Nile virus (WNV) has emerged in recent years in temperate regions of Europe and North America, presenting a threat to both public and animal health. The most serious manifestation of infection is fatal encephalitis in humans and horses, as well as mortality in certain domestic and wild birds. A recent development in the epizootiology of this mosquito-borne flavivirus was the occurrence of ...
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Inactivation of West Nile virus (WNV) in enzyme-linked immunosorbent assay (ELISA) wash buffer at 37 degrees C was studied, as well as inactivation of WNV in cell culture medium over several days at an ambient temperature (28 degrees C). Aliquots of WNV were removed from the 37 degrees C ELISA wash buffer at 5, 15, 30, and 60 min for the former experiment, while daily aliquots of medium were sa...
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Cytotoxic T lymphocytes (CTL) play an important role in the control and elimination of infection by West Nile virus (WNV), yet the class I human leukocyte antigen (HLA)-presented peptide epitopes that enable CTL recognition of WNV-infected cells remain uncharacterized. The goals of this work were first to discover the peptide epitopes that distinguish the class I HLA of WNV-infected cells and t...
متن کاملResurgence of West Nile Virus in 2012: Lack of Evidence for Viral Genetic Determinants
Since the introduction into North America in 1999 of West Nile virus (WNV) and its subsequent dramatic spread across the United States and Canada, human cases of WNV infection declined from their 2003 peak of 9,862 to only 712 cases and 43 fatalities confirmed in 2011 (http://www.cdc .gov/ncidod/dvbid/westnile/index.htm). The reasons for this decline remain unclear because avian amplification h...
متن کامل[West nile virus infection: re-emergent disease in Croatia].
West Nile virus (WNV) is a small, enveloped, spherical virus that belongs to the family Flaviviridae, genus Flavivirus, Japanese encephalitis serocomplex. Natural reservoirs of WNV are birds, and the main vectors are mosquitoes of the genus Culex. There are seven genetic lineages of WNV. Lineages 1 and 2 are the most widely distributed (Africa, North and South America, Europe, Asia and Australi...
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ژورنال
عنوان ژورنال: Vox Sanguinis
سال: 2004
ISSN: 0042-9007,1423-0410
DOI: 10.1111/j.1423-0410.2004.00530.x